Nadia Go

Discovery at your fingertips

Power your research with Nadia Go

A compact and affordable microfluidic system

Solve the frustrations associated with cumbersome modular systems and open the pathway to development, regardless of your level of microfluidic expertise.

Customize

parameters to create user-defined protocols and applications

Develop

new microfluidic based workflows

Discover

the unlimited possibilities of an open platform, built for novel microfluidic research and custom genomics projects.

The benefits of Nadia Go

The Nadia Go was created for researchers interested in development who do not require the scalable production features of the Nadia Instrument. The Nadia Go offers the customizable parameters of the Nadia Innovate without the necessity of purchasing a Nadia Instrument alongside it.

What is Nadia Go?

Nadia Go is a standalone, compact microfluidic tool providing a workstation for development and test of new protocols on a single Nadia chip. Cells, proteins, mRNA and a variety of other biologicals can be encapsulated with a wide range of buffers depending on sample needs.

Nadia Innovate and Nadia Go

Flexible

Open configurable system to develop new protocols and applications

 

Rapid protocol optimization

User-defined adjustment of droplet size, frequency, droplet components, temperature, and agitation

Easy process visualization

High-speed microscope and camera for real-time observation of droplet formation

Flexible PC software

Easy-to-use software to control the Nadia Go and create, change, test, and save new protocols

Easy software-controlled adjustments of

critical parameters on the Nadia Go

Temperature

Temperature control is essential in many biological applications, and requirements vary depending on experimental needs.

For example, whilst keeping a cell sample at cold temperature helps maintain the transcriptome state, the production of hydrogel beads with agarose requires heating to keep the agarose molten.

With Nadia Innovate and Nadia Go, control the temperature from 4 – 40°C at every step, from sample loading, to during the run, to post-run incubation temperature.

Time

Adapt pre – and post run incubation steps to suit your sample type. 

Or change the duration of a run to process different sample input volumes.

Stirring

To ensure an even distribution of cells and beads (if using beads) in droplets throughout a run, it is crucial to keep both in suspension as they will otherwise settle at the bottom of their respective wells, resulting in higher doublet rates.

On the Nadia Innovate and Nadia Go, stirring of cells and beads can be controlled individually, and stirring speeds can be changed dependent on cell and/or bead densities and properties.

Pressure

Precise pressure control of 3 independent channels up to 1 bar to ensure flexibility and precision of droplet formation.

Adjust presures of individual inputs to achieve optimal droplet formation to suit the cell size, buffer composition and viscosity, or bead material of the experiment.

We are developing novel single cell sequencing applications that go above and beyond standard scRNA-Seq methodologies. This has all been possible because of the Nadia system.

– Dr. Adam Cribbs, Group leader, Botnar research Centre, University of Oxford

Nadia Go workflow

Your idea

Sample input

Optimize

Discover

Analysis

Publish

Learn more about Nadia Go

Watch

The Nadia Go intro video

Download the Nadia Go flyer

Watch

Introducing the Nadia Innovate

FAQs

Are the chips single-use consumables?

The Nadia Chip is a single-use consumables which is discarded after a run. 

How do I clean my Nadia instrument/Innovate/Go?

The Nadia product family does not have wetted parts and therefore doesn’t require cleaning. Chips are one time use and are therefore disposed of after every experiment. For re-use and cleaning of Click Chips, please refer to the Click Chip User Manual 

How do I know what products/consumables/accessories I need?

We are able to advise you and produce system quotes on products if you are unsure of what you need to run your application. Please contact us.

Will my biological work with your systems?

In most cases, yes, your biological will work with the system. Whether a biological is compatible or not is dependent on many things such as the size and fragility of the cells. Please contact our applications team at applications@www.dolomite-bio.com for a detailed list of cells that have been trialed in our Nadia product family.

What range of droplet sizes can you make on one chip?

On the Nadia Innovate, you can generate droplets <40 µm in diameter with Do Bio’s new 40 µm FACS Sortable Click Chip and up to 100 µm with the standard Nadia Innovate Chip.

Can you change buffers and reagents that are used in the system?

Yes, the Nadia Go is fully flexible, allowing the use of your own reagents and the development of applications.

What is the minimum exposure time on the microscope with the Nadia Innovate?

50 ms