The creation of non-natural nucleic acid molecules is of great interest to synthetic biology, allowing the development of artificial nucleotides for a wide range of applications. Because these nucleotides are not found in nature, naturally occurring polymerases struggle to process them, limiting researchers’ ability to form complex polymers. One approach to overcome this issue is the directed evolution of polymerases derived from Archaea and other extremophiles, but this technique is both labor intensive and difficult to perform on a large scale. Researchers at Arizona State University’s Biodesign Institute have turned to microfluidics to allow rapid sorting and screening of novel polymerases.
Blacktrace Holdings Limited, a leading group of companies focused on Productizing Science®, is pleased to announce the launch of its latest brand, Dolomite Bio. This biology-focused brand – spun out from sister company Dolomite Microfluidics – is dedicated to the development of innovative products for high throughput single cell research.
Dolomite Bio has developed the Meros High Speed Digital Microscope specifically for microfluidic applications. This high resolution imaging system allows users to conveniently monitor high speed microfluidic events, such as droplet formation, using a built-in stage.
Dolomite, part of the Blacktrace group of companies, is celebrating a decade of excellence in the design and manufacture of novel, high quality microfluidic products, including individual components such as pumps, chips, connectors, temperature controllers and sensors, software solutions and complete microfluidic systems.
Dolomite, a world leader in microfluidics innovation, has launched the Single Cell RNA-Seq Chip for simple, reliable creation of single cell libraries. This new chip allows researchers to use droplet-based microfluidic methods to help explore the behaviour of thousands of individual cells, providing a rapid and easy way to screen for new or cryptic cell types.