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ChatGPT, the trained model for open conversations by OpenAI has taken over the internet in recent weeks, used for fun things, such as having it invent stories about beavers to explain DevOps, to instantly creating code for you from scratch.I asked ChatGPT to explain...
With 2022 coming to an end, we wanted to reflect on everything exciting that happened in our Dolomite Bio community. In particular, we wanted to highlight the top 5 blogs of this year ranging from new a method for single cell long-read sequencing to an in-depth...
Single cell study for the population and signaling pathways of gastrointestinal stem cells niches In the human body, the development of distinct organs is regulated by specific stromal niche (mesenchymal stem cells) signals. For the stomach and intestines, epithelial...
History of microfluidicsA plethora of biological techniques have been developed in the past decade which allows the study of a large cell population. These techniques reveal a cellular heterogeneity that exists among different tissues or the same type of cells.This...
The Nadia Go - an open microfluidic systemWe are pleased to announce the new addition to the Nadia product family—The Nadia Go, which will combine the benefits of both the Nadia Instrument and Nadia Innovate. A single instrument, but with double the benefits!Dolomite...
The main goal, and challenge, in single-cell RNA sequencing data analysis is assigning cell type identity to cells. Performed after dimensionality reduction and clustering, this step gives a name to each cluster of cells. Even though annotation remains a difficult...
A (Very) Brief History of 3D cell cultureThe earliest studies related to 3D cell culture in the 80s highlighted the importance of 3D techniques for creating accurate in vitro culture models. The importance of the tissue microenvironment and 3D culturing techniques for...
An out-and-out solution for Agarose EncapsulationThe ideal habitat for cellsThe holy grail of cell culture methods would combine the high throughput encapsulation of cells in a 3D scaffold (spheroid) with the free perfusion of molecules whilst also compartmentalizing...
Dimension reduction methods - UMAPIn the previous blog, we introduced dimension reduction in single cell RNA-Sequencing (scRNA-Seq) as well as PCA and t-SNE dimension reduction methods. We have learned that single cell data are sparse, noisy, and high-dimensional and...
What is dimensionality reduction?Introduced in 2009, single-cell RNA sequencing (scRNA-Seq) allows researchers to observe cellular heterogeneity of the transcriptome at the resolution of individual cells. This method produces vast amounts of data with expression...