by Xuan Nguyen | Nov 16, 2022 | All Blogs
Single cell study for the population and signaling pathways of gastrointestinal stem cells niches In the human body, the development of distinct organs is regulated by specific stromal niche (mesenchymal stem cells) signals. For the stomach and intestines, epithelial...
by Xuan Nguyen | Sep 7, 2022 | All Blogs
The main goal, and challenge, in single-cell RNA sequencing data analysis is assigning cell type identity to cells. Performed after dimensionality reduction and clustering, this step gives a name to each cluster of cells. Even though annotation remains a difficult...
by Xuan Nguyen | Mar 8, 2022 | All Blogs, Bioinformatics & single cell data analysis blogs
Dimension reduction methods – UMAPIn the previous blog, we introduced dimension reduction in single cell RNA-Sequencing (scRNA-Seq) as well as PCA and t-SNE dimension reduction methods. We have learned that single cell data are sparse, noisy, and...
by Xuan Nguyen | Mar 8, 2022 | All Blogs, Bioinformatics & single cell data analysis blogs
What is dimensionality reduction?Introduced in 2009, single-cell RNA sequencing (scRNA-Seq) allows researchers to observe cellular heterogeneity of the transcriptome at the resolution of individual cells. This method produces vast amounts of data with expression...
by Xuan Nguyen | Mar 8, 2022 | All Blogs, Bioinformatics & single cell data analysis blogs
Dimension reduction methods – t-SNEIn the previous blog, we have introduced dimension reduction in single-cell RNA-Sequencing (scRNA-Seq) and PCA as one dimension reduction method. We have learned that single cell data are sparse, noisy, and high-dimensional and...
